The four concerts were an opportunity to listen to the first performance ever of as many compositions, which interpret the motion of comets and the four satellites of Jupiter, the dialogue between an astronomer and a satellite, and some researches by Leonardo da Vinci: 39P / OTERMA by Antonio Galanti, RX-J 18–56.5, or the animated satellite by Roberto Becheri, 5 Aphorisms on Leonardo da Vinci’s texts by Barbara Rettagliati, and Four satellites for orchestra by Gianmarco Contini.

The rooms of the Museum have also hosted the performance of: Useless Machines (2005-06) by Francesco Antonioni, inspired by the work of Bruno Munari and directed by Antonioni himself; The color of numbers (2012) by Paolo Furlani, a tribute to Paul Klee; and Pulsar (2014) by Ivano Battison, for three accordions.

The four topics of these meetings – Cosmic Dialogues, Dancing Stars, From Florence to the Stars, and Sonorous Machines – illustrated the historical-philosophical context of the subjects that inspired the concerts, focusing on the idea of astronomical travel, on the sonorous machines of Leonardo da Vinci, on the utility of “useless” machines, and on the path that led man to become an "inhabitant of the sky".

The room that houses the impressive cosmological model by Antonio Santucci and the adjacent ones have been transformed into sonorous spaces in which musicians and listeners-visitors were immersed. The four different interpretations of Serenata for a satellite (1969) by Bruno Maderna, conceived and directed by Luciano Garosi, involved a dozen instrumentalists, some of whom created real "musical orbits" around Santucci's sphere and a dialogue with quotations from Galileo’s Sidereus Nuncius.